製品: GPHN Antibody
カタログ: DF9531
タンパク質の説明: Rabbit polyclonal antibody to GPHN
アプリケーション: WB IHC
反応性: Human, Mouse
予測: Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 80 kDa; 80kD(Calculated).
ユニプロット: Q9NQX3
RRID: AB_2842727

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
GPHN Antibody detects endogenous levels of total GPHN.
RRID:
AB_2842727
引用形式: Affinity Biosciences Cat# DF9531, RRID:AB_2842727.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHN; GPHRYN; KIAA1385; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAAIAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Bovine
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NQX3 基板として

Site PTM Type Enzyme
R34 Methylation
T52 Phosphorylation
S54 Phosphorylation
K57 Ubiquitination
T96 Phosphorylation
T100 Phosphorylation
T139 Phosphorylation
S147 Phosphorylation
S188 Phosphorylation
S194 Phosphorylation
T198 Phosphorylation
T199 Phosphorylation
S200 Phosphorylation
S230 Phosphorylation
S250 Phosphorylation
T265 Phosphorylation
T266 Phosphorylation
S268 Phosphorylation
S270 Phosphorylation P06493 (CDK1) , Q00535 (CDK5) , P49841 (GSK3B)
T276 Phosphorylation
S277 Phosphorylation
S280 Phosphorylation
T281 Phosphorylation
S283 Phosphorylation
T286 Phosphorylation
S291 Phosphorylation
S294 Phosphorylation
S295 Phosphorylation
K296 Ubiquitination
S303 Phosphorylation
S305 Phosphorylation
S319 Phosphorylation
S371 Phosphorylation
S393 Phosphorylation
T402 Phosphorylation
S480 Phosphorylation
T570 Phosphorylation
S571 Phosphorylation
S575 Phosphorylation
T655 Phosphorylation

研究背景

機能:

Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

細胞の位置付け:

Cell junction>Synapse. Cell junction>Synapse>Postsynaptic cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cell projection>Dendrite. Cell junction>Synapse>Postsynaptic density.
Note: Cytoplasmic face of glycinergic postsynaptic membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homotrimer, homodimer and homooligomer. Interacts with GABARAP (By similarity). Interacts with SRGAP2 (via SH3 domain) (By similarity). Interacts with GABRA3. Interacts with GLRB. GABRA3 and GLRB occupy overlapping binding sites (By similarity). Interacts with ARHGAP32; IQSEC3, INSYN1 and INSYN2A (By similarity).

タンパク質ファミリー:

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the MoeA family.

研究領域

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > GABAergic synapse.

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