FOLR2 Antibody - #DF9518
製品: | FOLR2 Antibody |
カタログ: | DF9518 |
タンパク質の説明: | Rabbit polyclonal antibody to FOLR2 |
アプリケーション: | WB IF/ICC |
反応性: | Human, Mouse |
予測: | Bovine, Horse, Sheep, Rabbit, Dog |
分子量: | 29 kDa; 29kD(Calculated). |
ユニプロット: | P14207 |
RRID: | AB_2842714 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9518, RRID:AB_2842714.
折りたたみ/展開
beta hFR; FBP; FBP/PL 1; FBP2; fetal/placental; folate receptor 2 (fetal); Folate receptor 2; Folate receptor; Folate receptor beta; Folate receptor, fetal/placental; Folbp 2; Folbp2; Folr2; FOLR2_HUMAN; FR beta; FR P3; FR-beta; Placental folate binding protein; Placental folate-binding protein;
免疫原
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
- P14207 FOLR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P14207 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
N115 | N-Glycosylation | Uniprot | |
N195 | N-Glycosylation | Uniprot |
研究背景
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
N-glycosylated.
Cell membrane>Lipid-anchor. Secreted.
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Belongs to the folate receptor family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Human Diseases > Drug resistance: Antineoplastic > Antifolate resistance.
参考文献
Application: IF/ICC Species: Mouse Sample: RAW264.7 cells
Application: WB Species: Mouse Sample: Raw264.7 and MH7A cells
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