製品: Phospho-Tyrosine Hydroxylase (Ser19) Antibody
カタログ: AF3115
タンパク質の説明: Rabbit polyclonal antibody to Phospho-Tyrosine Hydroxylase (Ser19)
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Bovine, Sheep, Rabbit, Dog, Xenopus
分子量: 60kDa; 59kD(Calculated).
ユニプロット: P07101
RRID: AB_2834552

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Bovine(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
Phospho-Tyrosine Hydroxylase (Ser19) Antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at Serine 19.
RRID:
AB_2834552
引用形式: Affinity Biosciences Cat# AF3115, RRID:AB_2834552.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Dystonia 14; DYT14; DYT5b; EC 1.14.16.2; OTTHUMP00000011225; OTTHUMP00000011226; ple; Protein Pale; TH; The; TY3H_HUMAN; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; Tyrosine hydroxylase;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P07101 TY3H_HUMAN:

Mainly expressed in the brain and adrenal glands.

タンパク質の説明:
Tyrosine hydroxylase (EC 1.14.16.2) is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
タンパク質配列:
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Pig
0
Horse
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P07101 基板として

Site PTM Type Enzyme
T3 Phosphorylation
S19 Phosphorylation Q8IW41 (MAPKAPK5) , P49137 (MAPKAPK2) , Q9UQM7 (CAMK2A)
S40 Phosphorylation P49137 (MAPKAPK2) , P51812 (RPS6KA3) , O75582 (RPS6KA5)
S62 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3)
S71 Phosphorylation P49137 (MAPKAPK2) , P51812 (RPS6KA3) , P17612 (PRKACA) , Q9UQM7 (CAMK2A)
S118 Phosphorylation
Y230 Phosphorylation
Y419 Phosphorylation
S502 Phosphorylation

研究背景

機能:

Plays an important role in the physiology of adrenergic neurons.

組織特異性:

Mainly expressed in the brain and adrenal glands.

タンパク質ファミリー:

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

研究領域

· Human Diseases > Neurodegenerative diseases > Parkinson's disease.

· Human Diseases > Substance dependence > Cocaine addiction.

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Substance dependence > Alcoholism.

· Metabolism > Amino acid metabolism > Tyrosine metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

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