| 製品: | APOBEC3H Antibody |
| カタログ: | DF9445 |
| タンパク質の説明: | Rabbit polyclonal antibody to APOBEC3H |
| アプリケーション: | WB |
| 反応性: | Human, Rat |
| 分子量: | 24 kDa(Observed); 24kD(Calculated). |
| ユニプロット: | Q6NTF7 |
| RRID: | AB_2842641 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9445, RRID:AB_2842641.
折りたたみ／展開
A3H; APOBEC related protein 10; APOBEC3H; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3H; ARP 10; DNA dC->dU-editing enzyme APOBEC-3H;
免疫原
A synthesized peptide derived from human APOBEC3H, corresponding to a region within C-terminal amino acids.
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
- Q6NTF7 ABC3H_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGYFENKKKCHAEICFINEIKSMGLDETQCYQVTCYLTWSPCSSCAWELVDFIKAHDHLNLGIFASRLYYHWCKPQQKGLRLLCGSQVPVEVMGFPEFADCWENFVDHEKPLSFNPYKMLEELDKNSRAIKRRLERIKIPGVRAQGRYMDILCDAEV
研究背景
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Nucleus. Cytoplasm. Cytoplasm>P-body.
Note: Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
Belongs to the cytidine and deoxycytidylate deaminase family.
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