| 製品: | CABP1 Antibody |
| カタログ: | DF9304 |
| タンパク質の説明: | Rabbit polyclonal antibody to CABP1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Chicken |
| 分子量: | 40 kDa(Observed); 40kD(Calculated). |
| ユニプロット: | Q9NZU7 |
| RRID: | AB_2842500 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9304, RRID:AB_2842500.
折りたたみ／展開
CABP 1; CaBP1; CABP1_HUMAN; Calbrain; Calcium binding protein 1; Calcium binding protein 5; Calcium-binding protein 1; Caldendrin; HCALB BR; HCALB_BR;
免疫原
A synthesized peptide derived from human CABP1, corresponding to a region within the internal amino acids.
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
- Q9NZU7 CABP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGGGDGAAFKRPGDGARLQRVLGLGSRREPRSLPAGGPAPRRTAPPPPGHASAGPAAMSSHIAKSESKTSLLKAAAAAASGGSRAPRHGPARDPGLPSRRLPGSCPATPQSSGDPSSRRPLCRPAPREEGARGSQRVLPQAHCRPREALPAAASRPSPSSPLPPARGRDGEERGLSPALGLRGSLRARGRGDSVPAAASEADPFLHRLRPMLSSAFGQDRSLRPEEIEELREAFREFDKDKDGYINCRDLGNCMRTMGYMPTEMELIELSQQINMNLGGHVDFDDFVELMGPKLLAETADMIGVKELRDAFREFDTNGDGEISTSELREAMRKLLGHQVGHRDIEEIIRDVDLNGDGRVDFEEFVRMMSR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina (By similarity).
Phosphorylated. The phosphorylation regulates the activity.
Cytoplasm>Cytoskeleton. Cytoplasm>Perinuclear region. Cell membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus. Cell junction>Synapse>Postsynaptic density.
Note: L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane.
Cytoplasm>Cytoskeleton.
Note: L-CaBP1 is associated most likely with the cytoskeletal structures.
Cytoplasm>Cell cortex. Cell membrane>Lipid-anchor.
Note: S-CaBP1 is localized at or near the plasma membrane.
Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
EF-1 binds magnesium constitutively under physiological conditions, EF-3 and EF-4 bind calcium cooperatively and EF-2 binds neither calcium nor magnesium.
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