ADAMDEC1 Antibody - #DF9167

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製品: ADAMDEC1 Antibody
カタログ: DF9167
タンパク質の説明: Rabbit polyclonal antibody to ADAMDEC1
アプリケーション: WB IHC IF/ICC
Cited expt.: WB, IF/ICC
反応性: Human, Mouse
分子量: 53kDa(Observed); 53kD(Calculated).
ユニプロット: O15204
RRID: AB_2842363

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#DF9167-BP

ADAMDEC1 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse
クローナリティ:
Polyclonal
特異性:
ADAMDEC1 Antibody detects endogenous levels of total ADAMDEC1.
RRID:
AB_2842363
引用形式: Affinity Biosciences Cat# DF9167, RRID:AB_2842363.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

A disintegrin and metalloproteinase domain like protein decysin 1; A disintegrin and metalloproteinase domain-like protein decysin-1; ADAM DEC1; ADAM like decysin 1; ADAM like protein decysin 1; ADAM-like protein decysin-1; ADAMDEC 1; Adamdec1; ADEC1_HUMAN; Decysin; Disintegrin protease; M12.219;

免疫原

免疫原:

A synthesized peptide derived from human ADAMDEC1, corresponding to a region within C-terminal amino acids.

Uniprot:

O15204(ADEC1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ADAMDEC1(27299)
発現特異性:
O15204 ADEC1_HUMAN:

Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

タンパク質配列:
MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE

研究背景

機能:

May play an important role in the control of the immune response and during pregnancy.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

参考文献

1). ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020 (PubMed: 31627897) [IF=2.5]

Application: IF/ICC    Species: mouse    Sample: macrophages

Fig. 2. ADAMDEC1 was located at macrophages and upregulated in M1 macrophages. (A) Co-localization of F4/80 and ADAMDEC1 in sections from LL37-induced mice model.

Application: WB    Species: mouse    Sample: macrophages

Fig. 3. |Knocking down of ADAMDEC1 impeded M1 macrophage activation. Macrophages were transfected with ADAMDEC1 siRNA (siAdam-1 and siAdam-2) (n ¼ 3) and negative control siRNA (siCtrl) (n ¼ 3) separately for 48 h. (A) ADAMDEC1 protein and mRNA level were detected in transfected human monocyte-derived macrophages.

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