ALKBH7 Antibody - #DF9074
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9074, RRID:AB_2842270.
折りたたみ／展開
ABH7; ALKB7_HUMAN; ALKBH7; Alkylated DNA repair protein alkB homolog 7; MGC10974; Probable alpha-ketoglutarate-dependent dioxygenase ABH7; SPATA11; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; UNQ6002; UNQ6002/PRO34564;
免疫原
A synthesized peptide derived from human ALKBH7, corresponding to a region within the internal amino acids.
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
- Q9BT30 ALKB7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGTGLLALRTLPGPSWVRGSGPSVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILQRVQAAAFGPGQTLLSSVHVLDLEARGYIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGESGQPPPAC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity).
Mitochondrion matrix.
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Belongs to the alkB family.
Restrictive clause
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