製品: VNN2 Antibody
カタログ: DF9037
タンパク質の説明: Rabbit polyclonal antibody to VNN2
アプリケーション: WB IF/ICC
反応性: Human, Mouse
予測: Bovine, Horse, Sheep
分子量: 59 kDa; 59kD(Calculated).
ユニプロット: O95498
RRID: AB_2842233

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製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Bovine(88%), Horse(100%), Sheep(88%)
クローナリティ:
Polyclonal
特異性:
VNN2 Antibody detects endogenous levels of total VNN2.
RRID:
AB_2842233
引用形式: Affinity Biosciences Cat# DF9037, RRID:AB_2842233.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

FOAP-4; Glycosylphosphatidyl inositol-anchored protein GPI-80; GPI-80; OTTHUMP00000017228; OTTHUMP00000233789; OTTHUMP00000233791; pantetheinase; Protein FOAP-4; vanin 2; Vanin-2; Vannin 2; Vascular non-inflammatory molecule 2;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O95498 VNN2_HUMAN:

Widely expressed with higher expression in spleen and blood.

タンパク質配列:
MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
88
Sheep
88
Rabbit
75
Pig
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95498 基板として

Site PTM Type Enzyme
T119 Phosphorylation
N411 N-Glycosylation

研究背景

機能:

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.

細胞の位置付け:

Cell membrane>Lipid-anchor.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed with higher expression in spleen and blood.

タンパク質ファミリー:

Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.

研究領域

· Metabolism > Metabolism of cofactors and vitamins > Pantothenate and CoA biosynthesis.

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