APOBEC3C Antibody - #DF8876
| 製品: | APOBEC3C Antibody |
| カタログ: | DF8876 |
| タンパク質の説明: | Rabbit polyclonal antibody to APOBEC3C |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 分子量: | 23 kDa; 23kD(Calculated). |
| ユニプロット: | Q9NRW3 |
| RRID: | AB_2842072 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8876, RRID:AB_2842072.
折りたたみ／展開
A3C; ABC3C_HUMAN; APOBEC1 like; APOBEC1-like; APOBEC1L; APOBEC3C; Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; ARDC2; ARDC4; ARP5; bK150C2.3; DNA dC >dU editing enzyme APOBEC 3C; MGC19485; PBI; Phorbolin I; Phorbolin I protein; Probable DNA dC dU editing enzyme APOBEC 3C; Probable DNA dC->dU-editing enzyme APOBEC-3C;
免疫原
A synthesized peptide derived from human APOBEC3C, corresponding to a region within C-terminal amino acids.
Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
- Q9NRW3 ABC3C_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
研究背景
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Nucleus. Cytoplasm.
Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary.
Belongs to the cytidine and deoxycytidylate deaminase family.
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