COASY Antibody - #DF8821
| 製品: | COASY Antibody |
| カタログ: | DF8821 |
| タンパク質の説明: | Rabbit polyclonal antibody to COASY |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 62 kDa; 62kD(Calculated). |
| ユニプロット: | Q13057 |
| RRID: | AB_2842018 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8821, RRID:AB_2842018.
折りたたみ／展開
Bifunctional coenzyme A synthase; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; COASY; COASY_HUMAN; Coenzyme A synthase; Dephospho-CoA kinase; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; DPCK; DPCOAK; NBP; Nucleotide binding protein; Pantetheine-phosphate adenylyltransferase; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; pOV 2; POV-2; POV2; PPAT; UKR1;
免疫原
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.
- Q13057 COASY_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAVFRSGLLVLTTPLASLAPRLASILTSAARLVNHTLYVHLQPGMSLEGPAQPQSSPVQATFEVLDFITHLYAGADVHRHLDVRILLTNIRTKSTFLPPLPTSVQNLAHPPEVVLTDFQTLDGSQYNPVKQQLVRYATSCYSCCPRLASVLLYSDYGIGEVPVEPLDVPLPSTIRPASPVAGSPKQPVRGYYRGAVGGTFDRLHNAHKVLLSVACILAQEQLVVGVADKDLLKSKLLPELLQPYTERVEHLSEFLVDIKPSLTFDVIPLLDPYGPAGSDPSLEFLVVSEETYRGGMAINRFRLENDLEELALYQIQLLKDLRHTENEEDKVSSSSFRQRMLGNLLRPPYERPELPTCLYVIGLTGISGSGKSSIAQRLKGLGAFVIDSDHLGHRAYAPGGPAYQPVVEAFGTDILHKDGIINRKVLGSRVFGNKKQLKILTDIMWPIIAKLAREEMDRAVAEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQALD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13057 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T13 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S172 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| T199 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| K379 | Ubiquitination | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| S507 | Phosphorylation | Uniprot | |
| K554 | Ubiquitination | Uniprot | |
| K558 | Ubiquitination | Uniprot |
研究背景
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
Cytoplasm. Mitochondrion matrix.
Note: The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but is also present in cell lysate.
Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain.
Monomer.
In the central section; belongs to the eukaryotic CoaD family.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Pantothenate and CoA biosynthesis.
· Metabolism > Global and overview maps > Metabolic pathways.
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