Phospho-OSR1 (Thr185) Antibody - #DF8742
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8742, RRID:AB_2841946.
折りたたみ／展開
2210022N24Rik; 2810422B09Rik; AI462649; AW209236; KIAA1101; mKIAA1101; OSR 1; OSR1; OTTHUMP00000209062; Oxidative stress responsive 1; Oxidative stress responsive 1 protein; Oxidative stress-responsive 1 protein; OXSR 1; OXSR1; OXSR1_HUMAN; Serine/threonine protein kinase OSR1; Serine/threonine-protein kinase OSR1;
免疫原
- O95747 OXSR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95747 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| K42 | Acetylation | Uniprot | |
| K46 | Acetylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| K114 | Ubiquitination | Uniprot | |
| K139 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| T185 | Phosphorylation | Q9H4A3 (WNK1) | Uniprot |
| T189 | Phosphorylation | Uniprot | |
| K254 | Ubiquitination | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| S269 | Phosphorylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| R287 | Methylation | Uniprot | |
| K297 | Methylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| T310 | Phosphorylation | Uniprot | |
| S312 | Phosphorylation | Uniprot | |
| S324 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Q9H4A3 (WNK1) | Uniprot |
| T331 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | P42345 (MTOR) | Uniprot |
| S347 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| T430 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S443 | Phosphorylation | Uniprot | |
| K444 | Methylation | Uniprot | |
| R451 | Methylation | Uniprot | |
| S510 | Phosphorylation | Uniprot |
PTMs - O95747 酵素として
| Substrate | Site | Source |
|---|---|---|
| P55011 (SLC12A2) | T203 | Uniprot |
| P55011 (SLC12A2) | T207 | Uniprot |
| P55011 (SLC12A2) | T212 | Uniprot |
| P55011 (SLC12A2) | T217 | Uniprot |
| P55011 (SLC12A2) | T230 | Uniprot |
| P55017 (SLC12A3) | T46 | Uniprot |
| P55017 (SLC12A3) | T55 | Uniprot |
| P55017 (SLC12A3) | T60 | Uniprot |
| P55017 (SLC12A3) | S73 | Uniprot |
| Q13153 (PAK1) | T84 | Uniprot |
| Q13621 (SLC12A1) | T95 | Uniprot |
| Q13621 (SLC12A1) | T100 | Uniprot |
| Q13621 (SLC12A1) | T105 | Uniprot |
| Q13621 (SLC12A1) | T118 | Uniprot |
| Q13621 (SLC12A1) | S120 | Uniprot |
研究背景
Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT.
Autophosphorylated.
Cytoplasm.
Ubiquitously expressed in all tissue examined.
Interacts with PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress (By similarity). Interacts with RELL1, RELL2 and RELT. Interacts with PLSCR1 in the presence of RELT.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
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For Research Use Only.
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