製品: RASSF4 Antibody
カタログ: DF8711
タンパク質の説明: Rabbit polyclonal antibody to RASSF4
アプリケーション: WB IF/ICC
反応性: Human, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 36 kDa; 37kD(Calculated).
ユニプロット: Q9H2L5
RRID: AB_2841915

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
予測:
Pig(100%), Bovine(90%), Horse(80%), Sheep(100%), Rabbit(90%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
RASSF4 Antibody detects endogenous levels of total RASSF4.
RRID:
AB_2841915
引用形式: Affinity Biosciences Cat# DF8711, RRID:AB_2841915.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

3830411C14Rik; AD037; AI586137; MGC105606; MGC44914; OTTHUMP00000019493; Ras association (RalGDS/AF 6) domain family 4; Ras association (RalGDS/AF 6) domain family member 4; Ras association domain containing protein 4; Ras association domain family 4; Ras association domain-containing protein 4; RASF4_HUMAN; RASSF 4; Rassf4; RP11-285G1.4; Tumor suppressor RASSF4;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9H2L5 RASF4_HUMAN:

Widely expressed. Frequently down-regulated in tumor cell lines.

タンパク質配列:
MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNGNITAQGPSIQPVHKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGERTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Sheep
100
Dog
100
Bovine
90
Rabbit
90
Horse
80
Zebrafish
57
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9H2L5 基板として

Site PTM Type Enzyme
K21 Ubiquitination
S91 Phosphorylation
S141 Phosphorylation
S168 Phosphorylation
K232 Methylation
S283 Phosphorylation

研究背景

機能:

Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.

組織特異性:

Widely expressed. Frequently down-regulated in tumor cell lines.

サブユニット構造:

Interacts directly with activated KRAS in a GTP-dependent manner.

研究領域

· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species.   (View pathway)

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