IGF2R Antibody - #DF8381
| 製品: | IGF2R Antibody |
| カタログ: | DF8381 |
| タンパク質の説明: | Rabbit polyclonal antibody to IGF2R |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus |
| 分子量: | 274kDa; 274kD(Calculated). |
| ユニプロット: | P11717 |
| RRID: | AB_2841642 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8381, RRID:AB_2841642.
折りたたみ／展開
300 kDa mannose 6 phosphate receptor; 300 kDa mannose 6-phosphate receptor; Cation independent mannose 6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CD222 antigen; CI Man 6 P receptor; CI Man-6-P receptor; CI MPR; CI-M6PR; CI-MPR; CIMPR; IGF 2 receptor; IGF 2R; IGF II receptor; IGF-II receptor; IGF2 receptor; Igf2r; Insulin like growth factor 2 receptor; Insulin like growth factor II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; mannose 6 phosphate receptor; mannose 6 phosphate receptor, cation independent; MPR 300; MPR300; MPRI; MPRI_HUMAN;
免疫原
- P11717 MPRI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P11717 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R7 | Methylation | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| N112 | N-Glycosylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| N581 | N-Glycosylation | Uniprot | |
| N626 | N-Glycosylation | Uniprot | |
| K687 | Ubiquitination | Uniprot | |
| Y700 | Phosphorylation | Uniprot | |
| Y701 | Phosphorylation | Uniprot | |
| Y709 | Phosphorylation | Uniprot | |
| R710 | Methylation | Uniprot | |
| N747 | N-Glycosylation | Uniprot | |
| K808 | Ubiquitination | Uniprot | |
| K833 | Ubiquitination | Uniprot | |
| K1052 | Ubiquitination | Uniprot | |
| K1104 | Ubiquitination | Uniprot | |
| T1107 | Phosphorylation | Uniprot | |
| T1111 | Phosphorylation | Uniprot | |
| K1230 | Ubiquitination | Uniprot | |
| N1246 | N-Glycosylation | Uniprot | |
| K1264 | Ubiquitination | Uniprot | |
| T1272 | Phosphorylation | Uniprot | |
| K1277 | Sumoylation | Uniprot | |
| S1280 | Phosphorylation | Uniprot | |
| S1281 | Phosphorylation | Uniprot | |
| K1293 | Ubiquitination | Uniprot | |
| K1301 | Ubiquitination | Uniprot | |
| T1346 | Phosphorylation | Uniprot | |
| S1347 | Phosphorylation | Uniprot | |
| Y1592 | Phosphorylation | Uniprot | |
| K1601 | Ubiquitination | Uniprot | |
| S1771 | Phosphorylation | Uniprot | |
| T1774 | Phosphorylation | Uniprot | |
| K1776 | Ubiquitination | Uniprot | |
| T1828 | Phosphorylation | Uniprot | |
| S1831 | Phosphorylation | Uniprot | |
| K1862 | Ubiquitination | Uniprot | |
| S1865 | Phosphorylation | Uniprot | |
| S1871 | Phosphorylation | Uniprot | |
| K1873 | Ubiquitination | Uniprot | |
| T2002 | Phosphorylation | Uniprot | |
| Y2024 | Phosphorylation | Uniprot | |
| Y2025 | Phosphorylation | Uniprot | |
| T2087 | Phosphorylation | Uniprot | |
| Y2154 | Phosphorylation | Uniprot | |
| S2189 | Phosphorylation | Uniprot | |
| T2209 | Phosphorylation | Uniprot | |
| S2210 | Phosphorylation | Uniprot | |
| K2338 | Ubiquitination | Uniprot | |
| S2346 | Phosphorylation | Uniprot | |
| S2347 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S2350 | Phosphorylation | Uniprot | |
| Y2351 | Phosphorylation | Uniprot | |
| K2352 | Acetylation | Uniprot | |
| K2352 | Ubiquitination | Uniprot | |
| Y2353 | Phosphorylation | Uniprot | |
| S2354 | Phosphorylation | Uniprot | |
| T2362 | Phosphorylation | Uniprot | |
| K2383 | Ubiquitination | Uniprot | |
| K2394 | Ubiquitination | Uniprot | |
| S2395 | Phosphorylation | Uniprot | |
| S2400 | Phosphorylation | Uniprot | |
| S2401 | Phosphorylation | Uniprot | |
| S2409 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T2415 | Phosphorylation | Uniprot | |
| K2420 | Ubiquitination | Uniprot | |
| R2425 | Methylation | Uniprot | |
| K2470 | Ubiquitination | Uniprot | |
| K2476 | Ubiquitination | Uniprot | |
| S2479 | Phosphorylation | Uniprot | |
| S2484 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
研究背景
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
Lysosome membrane>Single-pass type I membrane protein.
Note: Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.
Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
Belongs to the MRL1/IGF2R family.
研究領域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.