| 製品: | EBI3 Antibody |
| カタログ: | DF8363 |
| タンパク質の説明: | Rabbit polyclonal antibody to EBI3 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Dog |
| 分子量: | 25 kDa(Observed); 25kD(Calculated). |
| ユニプロット: | Q14213 |
| RRID: | AB_2841628 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8363, RRID:AB_2841628.
折りたたみ／展開
cytokine receptor; EBI3; EBV induced gene 3 protein; EBV-induced gene 3 protein; Epstein Barr virus induced 3; Epstein Barr virus induced gene 3; Epstein Barr virus induced gene 3 protein; Epstein-Barr virus-induced gene 3 protein; IL 27 subunit beta; IL 27B; IL-27 subunit beta; IL-27B; IL27 subunit; IL27 subunit beta; IL27B; IL27B_HUMAN; IL35 subunit; interleukin 27 subunit beta; Interleukin-27 subunit beta;
免疫原
A synthesized peptide derived from human EBI3, corresponding to a region within N-terminal amino acids.
- Q14213 IL27B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Secreted.
Belongs to the type I cytokine receptor family. Type 3 subfamily.
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