IL22 Antibody - #DF8343

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製品: IL22 Antibody
カタログ: DF8343
タンパク質の説明: Rabbit polyclonal antibody to IL22
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Dog
分子量: 20 kDa; 20kD(Calculated).
ユニプロット: Q9GZX6
RRID: AB_2841610

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MS Report
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(88%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
IL22 Antibody detects endogenous levels of total IL22.
RRID:
AB_2841610
引用形式: Affinity Biosciences Cat# DF8343, RRID:AB_2841610.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cytokine Zcyto18; IL 10 related T cell derived inducible factor; IL 21; IL 22; IL D110; IL TIF; IL-10-related T-cell-derived-inducible factor; IL-22; IL-TIF; IL21; Il22; IL22_HUMAN; ILD110; ILTIF; Interleukin 10 related T cell derived inducible factor; interleukin 21; Interleukin 22; Interleukin-22; MGC79382; MGC79384; TIFa; TIFIL 23; TIFIL23; UNQ3099/PRO10096; zcyto18;

免疫原

免疫原:
Uniprot:

Q9GZX6(IL22_HUMAN) >>Visit HPA database.

遺伝子(ID):
IL22(50616)
タンパク質配列:
MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
100
Pig
88
Horse
79
Rabbit
74
Chicken
67
Bovine
63
Sheep
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9GZX6 基板として

Site PTM Type Enzyme
N54 N-Glycosylation
N97 N-Glycosylation
S126 Phosphorylation

研究背景

機能:

Cytokine that contributes to the inflammatory response in vivo.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the IL-10 family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).

· Organismal Systems > Immune system > Th17 cell differentiation.   (View pathway)

参考文献

1). Th22 cells induce Müller cell activation via the Act1/TRAF6 pathway in diabetic retinopathy. CELL AND TISSUE RESEARCH, 2022 (PubMed: 36201050) [IF=3.6]
2). Chlamydia muridarum Alleviates Colitis via the IL-22/Occludin Signal Pathway. Biomed Research International, 2020 (PubMed: 33381598)

Application: WB    Species: Mice    Sample: colon tissue

Figure 3 Chlamydia muridarum upregulates IL-22 and occludin expression in mice with dextran sodium sulfate- (DSS-) induced colitis. (a) IL-22 and occludin expression in various groups assessed using western blotting. (b) Relative protein expression of IL-22 and occludin. (n = 3 per group). ∗P < 0.05, DSS group compared with control group; #P < 0.05, CM+DSS group compared with DSS group; &P < 0.05, CM+DSS+aIL-22 group compared with CM+DSS group.

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.