SERPINA6 Antibody - #DF8283

(1)  
製品: SERPINA6 Antibody
カタログ: DF8283
タンパク質の説明: Rabbit polyclonal antibody to SERPINA6
アプリケーション: WB IF/ICC
反応性: Human
分子量: 60 kDa; 45kD(Calculated).
ユニプロット: P08185
RRID: AB_2841570

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500, WB 1:1000-3000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
SERPINA6 Antibody detects endogenous levels of total SERPINA6.
RRID:
AB_2841570
引用形式: Affinity Biosciences Cat# DF8283, RRID:AB_2841570.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CBG; CBG_HUMAN; corticosteroid binding globulin; Corticosteroid-binding globulin; serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpin A6; serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6; Serpina6; Transcortin;

免疫原

免疫原:

A synthesized peptide derived from human SERPINA6, corresponding to a region within the internal amino acids.

Uniprot:

P08185(CBG_HUMAN) >>Visit HPA database.

遺伝子(ID):
SERPINA6(866)
発現特異性:
P08185 CBG_HUMAN:

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

タンパク質配列:
MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFTWSSLFLARVMNPV

研究背景

機能:

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

PTMs:

N-glycosylated; binds 5 oligosaccharide chains.

Glycosylation in position Asn-260 is needed for steroid binding.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

タンパク質ファミリー:

Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.

Belongs to the serpin family.

Restrictive clause

 

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