ORM2 Antibody - #DF8280

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製品: ORM2 Antibody
カタログ: DF8280
タンパク質の説明: Rabbit polyclonal antibody to ORM2
アプリケーション: WB IF/ICC
反応性: Human, Rat
分子量: 24 kDa; 24kD(Calculated).
ユニプロット: P19652
RRID: AB_2841568

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
クローナリティ:
Polyclonal
特異性:
ORM2 Antibody detects endogenous levels of total ORM2.
RRID:
AB_2841568
引用形式: Affinity Biosciences Cat# DF8280, RRID:AB_2841568.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

AGP B'; AGP 2; AGP B; AGP2; Alpha 1 acid glycoprotein 2; Alpha 1 acid glycoprotein type 2; OMD 2; ORM 2; Orosomucoid2;

免疫原

免疫原:

A synthesized peptide derived from human ORM2, corresponding to a region within the internal amino acids.

Uniprot:

P19652(A1AG2_HUMAN) >>Visit HPA database.

遺伝子(ID):
ORM2(5005)
発現特異性:
P19652 A1AG2_HUMAN:

Expressed by the liver and secreted in plasma.

タンパク質配列:
MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES

研究背景

機能:

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

PTMs:

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by the liver and secreted in plasma.

タンパク質ファミリー:

Contains a beta-barrel that binds various ligands in its interior.

Belongs to the calycin superfamily. Lipocalin family.

参考文献

1). 3-Hydroxybutyrate Suppresses Colon Cancer Growth by Inducing Intracellular Lactate Accumulation and Oxidative Stress. Journal of proteome research, 2025 (PubMed: 40476748) [IF=3.8]

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