製品: SEPP1 Antibody
カタログ: DF8258
タンパク質の説明: Rabbit polyclonal antibody to SEPP1
アプリケーション: WB IHC
反応性: Human, Rat, Monkey
予測: Pig
分子量: 43 kDa; 43kD(Calculated).
ユニプロット: P49908
RRID: AB_2841548

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat,Monkey
予測:
Pig(80%)
クローナリティ:
Polyclonal
特異性:
SEPP1 Antibody detects endogenous levels of total SEPP1.
RRID:
AB_2841548
引用形式: Affinity Biosciences Cat# DF8258, RRID:AB_2841548.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Selenoprotein P; Selenoprotein P plasma 1; Selp; SeP; Sepp1; SEPP1_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human SEPP1, corresponding to a region within the internal amino acids.

Uniprot:
遺伝子(ID):
発現特異性:
P49908 SEPP1_HUMAN:

Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

タンパク質配列:
MWRSLGLALALCLLPSGGTESQDQSSLCKQPPAWSIRDQDPMLNSNGSVTVVALLQASUYLCILQASKLEDLRVKLKKEGYSNISYIVVNHQGISSRLKYTHLKNKVSEHIPVYQQEENQTDVWTLLNGSKDDFLIYDRCGRLVYHLGLPFSFLTFPYVEEAIKIAYCEKKCGNCSLTTLKDEDFCKRVSLATVDKTVETPSPHYHHEHHHNHGHQHLGSSELSENQQPGAPNAPTHPAPPGLHHHHKHKGQHRQGHPENRDMPASEDLQDLQKKLCRKRCINQLLCKLPTDSELAPRSUCCHCRHLIFEKTGSAITUQCKENLPSLCSUQGLRAEENITESCQURLPPAAUQISQQLIPTEASASURUKNQAKKUEUPSN

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
80
Horse
78
Bovine
75
Rabbit
63
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.

PTMs:

Phosphorylation sites are present in the extracellular medium.

細胞の位置付け:

Secreted.
Note: Passes from plasma into the glomerular filtrate where it is removed by endocytosis mediated by LRP2 in the proximal tubule epithelium.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Made in the liver and heart and secreted into the plasma. It is also found in the kidney.

タンパク質ファミリー:

The C-terminus is not required for endocytic uptake in the proximal tubule epithelium.

Belongs to the selenoprotein P family.

参考文献

1). Methylseleninic Acid Elevating the Nrf2-GPX4 Axis Relieves Endothelial Dysfunction and Ferroptosis Induced by Arsenic Exposure. Journal of agricultural and food chemistry, 2025 (PubMed: 40071728) [IF=5.7]

2). Single-cell transcriptomic analysis reveals that the APP-CD74 axis promotes immunosuppression and progression of testicular tumors. The Journal of pathology, 2024 (PubMed: 39161125) [IF=5.6]

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