CTSS Antibody - #DF8246

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製品: CTSS Antibody
カタログ: DF8246
タンパク質の説明: Rabbit polyclonal antibody to CTSS
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 37 kDa; 37kD(Calculated).
ユニプロット: P25774
RRID: AB_2841541

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 100ul $280 在庫あり
 200ul $350 在庫あり

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(83%), Bovine(92%), Horse(100%), Sheep(92%), Rabbit(92%), Dog(83%)
クローナリティ:
Polyclonal
特異性:
CTSS Antibody detects endogenous levels of total CTSS.
RRID:
AB_2841541
引用形式: Affinity Biosciences Cat# DF8246, RRID:AB_2841541.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Cathepsin S; CathepsinS; CATS_HUMAN; Ctss;

免疫原

免疫原:
Uniprot:

P25774(CATS_HUMAN) >>Visit HPA database.

遺伝子(ID):
CTSS(1520)
タンパク質配列:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
92
Sheep
92
Rabbit
92
Pig
83
Dog
83
Xenopus
75
Chicken
58
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P25774 基板として

Site PTM Type Enzyme
K42 Ubiquitination
S171 Phosphorylation
Y175 Phosphorylation
S200 Phosphorylation
Y215 Phosphorylation
S217 Phosphorylation
Y232 Phosphorylation
Y262 Phosphorylation

研究背景

機能:

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

細胞の位置付け:

Lysosome. Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Monomer.

タンパク質ファミリー:

Belongs to the peptidase C1 family.

研究領域

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

参考文献

1). Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage. Oxidative Medicine and Cellular Longevity (PubMed: 36226158)

Application: WB    Species: Mouse    Sample:

Figure 7 Validation of four candidates by Western blot and the correlation analysis between four candidates and behavior tests. (a) Representative Western blot bands and quantitative analysis of Itgb2, Serpina3n, Serping1, and Ctss protein expression. (b) Spearman's correlation analysis results showing the correlation between the protein expression levels of candidates and the scores of mGarcia test. (c) Spearman's correlation analysis results showing the correlation between the protein expression levels of candidates and the scores of beam walking test. n = 6 per group.

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For Research Use Only.
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