URM1 Antibody - #DF8215
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8215, RRID:AB_2841520.
折りたたみ／展開
2900073H19Rik; C9orf74; Chromosome 9 open reading frame 74; MGC2668; RGD1306599; RP11 339B21.4; RP23-443G7.1; Ubiquitin related modifier 1; Ubiquitin related modifier 1 homolog; Ubiquitin-related modifier 1 homolog; Urm 1; URM1; URM1_HUMAN;
免疫原
- Q9BTM9 URM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPLSVEVEFGGGAELLFDGIKKHRVTLPGQEEPWDIRNLLIWIKKNLLKERPELFIQGDSVRPGILVLINDADWELLGELDYQLQDQDSVLFISTLHGG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BTM9 基板として
| Site | PTM Type | Enzyme | Source |
|---|
研究背景
Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.
Cytoplasm.
Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
Belongs to the URM1 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Sulfur relay system. (View pathway)
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