CITED2 Antibody - #DF8113
| 製品: | CITED2 Antibody |
| カタログ: | DF8113 |
| タンパク質の説明: | Rabbit polyclonal antibody to CITED2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Sheep, Dog |
| 分子量: | 28 kDa; 28kD(Calculated). |
| ユニプロット: | Q99967 |
| RRID: | AB_2841455 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8113, RRID:AB_2841455.
折りたたみ／展開
ASD8; Cbp/p300 interacting transactivator 2; Cbp/p300 interacting transactivator with Glu/Asp rich carboxy terminal domain 2; Cbp/p300-interacting transactivator 2; CITE2_HUMAN; CITED 2; CITED2; melanocyte-specific gene 1-related gene 1; MRG 1; MRG-1; MRG1; MSG related protein 1; MSG-related protein 1; MSG1-related gene 1; P35srj; VSD2;
免疫原
A synthesized peptide derived from human CITED2, corresponding to a region within the internal amino acids.
- Q99967 CITE2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPAAGHQMNGTNQHFRDCNPKHSGGSSTPGGSGGSSTPGGSGSSSGGGAGSSNSGGGSGSGNMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Nucleus.
Note: Colocalizes with EP300 in dot-like structures.
Belongs to the CITED family.
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