TNC Antibody - #DF8051
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| 製品: | TNC Antibody |
| カタログ: | DF8051 |
| タンパク質の説明: | Rabbit polyclonal antibody to TNC |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 241 kDa; 241kD(Calculated). |
| ユニプロット: | P24821 |
| RRID: | AB_2841409 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF8051, RRID:AB_2841409.
折りたたみ／展開
150 225; Cytotactin; Glioma associated extracellular matrix antigen; Glioma-associated-extracellular matrix antigen; GMEM; GP 150 225; GP 150-225; GP; Hexabrachion; HXB; JI; MGC167029; Miotendinous antigen; Myotendinous antigen; Neuronectin; TENA_HUMAN; Tenascin; Tenascin-C; Tenascin-C isoform 14/AD1/16; TenascinC; TN; TN C; TN-C; TNC;
免疫原
- P24821 TENA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P24821 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S62 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S70 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| T91 | Phosphorylation | Uniprot | |
| N184 | N-Glycosylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| Y491 | Phosphorylation | Uniprot | |
| S616 | Phosphorylation | Uniprot | |
| K719 | Acetylation | Uniprot | |
| T800 | Phosphorylation | Uniprot | |
| S903 | Phosphorylation | Uniprot | |
| T905 | Phosphorylation | Uniprot | |
| T1007 | Phosphorylation | Uniprot | |
| N1018 | N-Glycosylation | Uniprot | |
| Y1019 | Phosphorylation | Uniprot | |
| S1020 | Phosphorylation | Uniprot | |
| T1023 | Phosphorylation | Uniprot | |
| N1034 | N-Glycosylation | Uniprot | |
| N1079 | N-Glycosylation | Uniprot | |
| N1093 | N-Glycosylation | Uniprot | |
| N1184 | N-Glycosylation | Uniprot | |
| N1261 | N-Glycosylation | Uniprot | |
| N1275 | N-Glycosylation | Uniprot | |
| N1301 | N-Glycosylation | Uniprot | |
| S1310 | Phosphorylation | Uniprot | |
| N1366 | N-Glycosylation | Uniprot | |
| Y1418 | Phosphorylation | Uniprot | |
| N1485 | N-Glycosylation | Uniprot | |
| T1492 | Phosphorylation | Uniprot | |
| T1502 | Phosphorylation | Uniprot | |
| S1699 | Phosphorylation | Uniprot | |
| T1701 | Phosphorylation | Uniprot | |
| S1703 | Phosphorylation | Uniprot | |
| T1751 | Phosphorylation | Uniprot | |
| T1760 | Phosphorylation | Uniprot | |
| Y1775 | Phosphorylation | Uniprot | |
| S1778 | Phosphorylation | Uniprot | |
| N1809 | N-Glycosylation | Uniprot | |
| T1842 | Phosphorylation | Uniprot | |
| T1844 | Phosphorylation | Uniprot | |
| S1846 | Phosphorylation | Uniprot | |
| T1878 | Phosphorylation | Uniprot | |
| T1885 | Phosphorylation | Uniprot | |
| S1889 | Phosphorylation | Uniprot | |
| T1902 | Phosphorylation | Uniprot | |
| T1906 | Phosphorylation | Uniprot | |
| Y2070 | Phosphorylation | Uniprot | |
| T2129 | Phosphorylation | Uniprot | |
| T2134 | Phosphorylation | Uniprot | |
| N2162 | N-Glycosylation | Uniprot |
研究背景
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells.
Secreted>Extracellular space>Extracellular matrix.
Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
Belongs to the tenascin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
参考文献
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