Ferritin Heavy Chain Antibody - #DF7705

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製品: Ferritin Heavy Chain Antibody
カタログ: DF7705
タンパク質の説明: Rabbit polyclonal antibody to Ferritin Heavy Chain
アプリケーション: WB IF/ICC
Cited expt.: WB
反応性: Human
予測: Pig, Bovine, Horse, Rabbit, Dog, Xenopus
分子量: 21 kDa(Observed); 21kD(Calculated).
ユニプロット: P02794
RRID: AB_2841175

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#DF7705-BP

Ferritin Heavy Chain Peptide

1mg
関連ダウンロード
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Pig(88%), Bovine(%), Horse(%), Rabbit(%), Dog(%), Xenopus(%)
クローナリティ:
Polyclonal
特異性:
Ferritin Heavy Chain Antibody detects endogenous levels of total Ferritin Heavy Chain.
RRID:
AB_2841175
引用形式: Affinity Biosciences Cat# DF7705, RRID:AB_2841175.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Apoferritin; Cell proliferation inducing gene 15 protein; Cell proliferation-inducing gene 15 protein; F HC; Ferritin H subunit; Ferritin heavy chain; Ferritin heavy polypeptide 1; FHC; FRIH; FRIH_HUMAN; FTH 1; FTH; FTH1; FTH1 protein; FTHL 6; FTHL6; Iron overload autosomal dominant; MGC104426; N-terminally processed; OK/SW-cl.84; PIG 15; PIG15; Placenta immunoregulatory factor; PLIF; Proliferation inducing gene 15 protein; Proliferation inducing protein 15;

免疫原

免疫原:

A synthesized peptide derived from human Ferritin Heavy Chain, corresponding to a region within C-terminal amino acids.

Uniprot:

P02794(FRIH_HUMAN) >>Visit HPA database.

遺伝子(ID):
FTH1(2495)
発現特異性:
P02794 FRIH_HUMAN:

Expressed in the liver.

タンパク質配列:
MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSDNES

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
88
Bovine
88
Dog
88
Xenopus
88
Rabbit
88
Horse
86
Sheep
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

組織特異性:

Expressed in the liver.

タンパク質ファミリー:

Belongs to the ferritin family.

研究領域

· Cellular Processes > Cell growth and death > Ferroptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Organismal Systems > Digestive system > Mineral absorption.

参考文献

1). Hsa_circ_0002301 inhibits ferroptosis in gastric cancer by encoding the de novo protein HECTD1-463aa. Journal of translational medicine, 2025 (PubMed: 40022084) [IF=7.4]

Application: WB    Species: Mouse    Sample:

Fig. 1 Elevated hsa_circ_0002301 expression is correlated with ferroptosis in a gastric cancer model.a. A mouse gastric cancer model induced by N-methyl-N-nitrosourea (MNU) was established. b. Ferroptosis indicators, such as Fe2+ accumulation, MDA levels, ROS levels, and the GSH/GSSG ratio, were assessed in the three groups. c. FNR protein expression was assessed in adjacent nontumor tissues and gastric cancer tissues from mice. (d) Tumor sections were spread for volume and weight measurements. (e) Hematoxylin and eosin (H&E) staining revealed the histopathological morphology of gastric cancer tissues with high ferroptosis levels, while Ki-67 staining revealed the cell proliferation capacity. Scale bar: 100 μm. (f) Expression of the 7 selected circRNAs in 46 pairs of gastric cancer and adjacent tissues from clinical samples obtained during surgery. The graph shows the mean ± standard deviation (SD) values; *p 

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