EPS15L1 Antibody - #DF7681
(1)
(4)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7681, RRID:AB_2841152.
折りたたみ／展開
EP15R_HUMAN; epidermal growth factor receptor pathway substrate 15- ike 1; Epidermal growth factor receptor substrate 15 like 1; Epidermal growth factor receptor substrate 15-like 1; epidermal growth factor receptor substrate EPS15R; Eps15 related protein; Eps15-related protein; EPS15L1; Eps15R;
免疫原
- Q9UBC2 EP15R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPLIPLSQQIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSAEAHWAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALLFSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSKGSDPFGTLDPFGSGSFNSAEGFADFSQMSKPPPSGPFTSSLGGAGFSDDPFKSKQDTPALPPKKPAPPRPKPPSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASASGFADFTSVS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UBC2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| S46 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| T106 | Phosphorylation | Uniprot | |
| S107 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T113 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S229 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| S238 | Phosphorylation | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| S246 | Phosphorylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| T251 | Phosphorylation | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S355 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| T366 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| S390 | Phosphorylation | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| S402 | Phosphorylation | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| T418 | Phosphorylation | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S486 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| T528 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K534 | Ubiquitination | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S548 | Phosphorylation | Uniprot | |
| S553 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| Y564 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot | |
| T577 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| K602 | Ubiquitination | Uniprot | |
| K604 | Ubiquitination | Uniprot | |
| T612 | Phosphorylation | Uniprot | |
| K627 | Ubiquitination | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| K638 | Ubiquitination | Uniprot | |
| K664 | Ubiquitination | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| S672 | Phosphorylation | Uniprot | |
| K679 | Ubiquitination | Uniprot | |
| K680 | Ubiquitination | Uniprot | |
| K683 | Ubiquitination | Uniprot | |
| S689 | Phosphorylation | Uniprot | |
| K694 | Ubiquitination | Uniprot | |
| S697 | Phosphorylation | Uniprot | |
| K701 | Ubiquitination | Uniprot | |
| S707 | Phosphorylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| S712 | Phosphorylation | Uniprot | |
| S714 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| S718 | Phosphorylation | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| S734 | Phosphorylation | Uniprot | |
| T776 | Phosphorylation | Uniprot | |
| K782 | Acetylation | Uniprot | |
| K783 | Acetylation | Uniprot | |
| S793 | Phosphorylation | Uniprot | |
| T797 | Phosphorylation | Uniprot | |
| K828 | Ubiquitination | Uniprot | |
| K829 | Ubiquitination | Uniprot | |
| K838 | Ubiquitination | Uniprot | |
| K848 | Ubiquitination | Uniprot | |
| K851 | Ubiquitination | Uniprot |
研究背景
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Phosphorylated on tyrosine residues by EGFR.
Cell membrane>Peripheral membrane protein. Nucleus. Membrane>Coated pit.
Note: Localized to plasma membrane coated pits.
Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with CAVIN3 (via leucine-zipper domain).
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
参考文献
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