hCG beta Antibody - #AF0177
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0177, RRID:AB_2833370.
折りたたみ／展開
CG beta; CG-beta; CGB; CGB3; CGB5; CGB7; CGB8; CGHB_HUMAN; Choriogonadotropin subunit beta; Chorionic gonadotrophin chain beta; Chorionic gonadotropin beta 3 subunit; Chorionic gonadotropin beta polypeptide; Chorionic gonadotropin beta subunit; hCGB;
免疫原
- P0DN86 CGB3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
PTMs - P0DN86 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| T117 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S141 | O-Glycosylation | Uniprot | |
| S147 | O-Glycosylation | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S152 | O-Glycosylation | Uniprot | |
| S152 | Phosphorylation | Uniprot | |
| S158 | O-Glycosylation | Uniprot |
研究背景
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
Secreted.
High expression in the placenta throughout pregnancy.
Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
Belongs to the glycoprotein hormones subunit beta family.
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