C3AR1 Antibody - #DF10198
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10198, RRID:AB_2840777.
折りたたみ／展開
AZ 3B; AZ3B; C3a anaphylatoxin chemotactic receptor; C3A R; C3A R1; C3a-R; C3AR; C3AR_HUMAN; C3AR1; C3R1; Complement component 3 receptor 1; Complement component 3a receptor 1; HNFAG09;
免疫原
Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
- Q16581 C3AR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16581 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S266 | O-Glycosylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| S349 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| T466 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot | |
| T481 | Phosphorylation | Uniprot |
研究背景
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
O-glycosylated.
Cell membrane>Multi-pass membrane protein.
Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
Interacts with VGF-derived peptide TLQP-21 (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
参考文献
Application: WB Species: mouse Sample: Hepa1-6 cells
Application: IF/ICC Species: mouse Sample: Hepa1-6 cells
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