| 製品: | DEDD Antibody |
| カタログ: | DF10100 |
| タンパク質の説明: | Rabbit polyclonal antibody to DEDD |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 37 kDa(Observed); 37kD(Calculated). |
| ユニプロット: | O75618 |
| RRID: | AB_2840680 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10100, RRID:AB_2840680.
折りたたみ／展開
CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; Death effector domain-containing protein; Death effector domain-containing testicular molecule; DEDD 1; dedD; DEDD_HUMAN; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED-1; FLDED1; KE 05; KE05; OTTHUMP00000031822;
免疫原
A synthesized peptide derived from human DEDD, corresponding to a region within the internal amino acids.
- O75618 DEDD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQMCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
Exists predominantly in a mono- or diubiquitinated form.
Cytoplasm. Nucleus>Nucleolus.
Note: Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells.
Widely expressed with highest levels in testis.
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