MAGEA2 Antibody - #DF10029
| 製品: | MAGEA2 Antibody |
| カタログ: | DF10029 |
| タンパク質の説明: | Rabbit polyclonal antibody to MAGEA2 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 35 kDa; 35kD(Calculated). |
| ユニプロット: | P43356 |
| RRID: | AB_2840609 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF10029, RRID:AB_2840609.
折りたたみ／展開
Cancer/testis antigen 1.2; Cancer/testis antigen family 1, member 2; CT1.2; MAGE 2; MAGE 2 antigen; MAGE2; MAGEA 2; MAGEA2; MAGEA2A; MAGEA2B; Melanoma antigen 2; Melanoma antigen family A, 2; Melanoma antigen family A, 2B; Melanoma antigen, family A, 2, copy b; Melanoma associated antigen 2;
免疫原
A synthesized peptide derived from human MAGEA2, corresponding to a region within C-terminal amino acids.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
- P43356 MAGA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE
研究背景
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.
Nucleus. Nucleus>PML body.
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
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