製品: Phospho-HSP105 (Ser809) Antibody
カタログ: AF8484
タンパク質の説明: Rabbit polyclonal antibody to Phospho-HSP105 (Ser809)
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 100kDa,120kDa; 97kD(Calculated).
ユニプロット: Q92598
RRID: AB_2840538

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(88%)
クローナリティ:
Polyclonal
特異性:
Phospho-HSP105 (Ser809) Antibody detects endogenous levels of HSP105 only when phosphorylated at Ser809.
RRID:
AB_2840538
引用形式: Affinity Biosciences Cat# AF8484, RRID:AB_2840538.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Antigen NY CO 25; Antigen NY-CO-25; DKFZp686M05240; Heat shock 105kD alpha; Heat shock 105kD; Heat shock 105kD beta; Heat shock 105kDa protein 1; Heat shock 105kDa protein; Heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock 110kDa protein; Heat shock protein 105 kDa; HS105_HUMAN; HSP105; HSP105A; HSP105B; HSP110; HSPH 1; Hsph1; KIAA0201; NY CO 25;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q92598 HS105_HUMAN:

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

タンパク質配列:
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
88
Chicken
75
Zebrafish
57
Pig
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q92598 基板として

Site PTM Type Enzyme
S2 Acetylation
S2 Phosphorylation
T25 Phosphorylation
S31 Phosphorylation
R33 Methylation
S43 Phosphorylation
K44 Ubiquitination
K53 Ubiquitination
K68 Acetylation
K68 Methylation
K68 Ubiquitination
K82 Ubiquitination
K84 Ubiquitination
Y89 Phosphorylation
K95 Ubiquitination
K102 Ubiquitination
K126 Ubiquitination
S132 Phosphorylation
T138 Phosphorylation
T149 Phosphorylation
K185 Ubiquitination
K194 Acetylation
K194 Ubiquitination
K221 Ubiquitination
K234 Acetylation
K234 Ubiquitination
K239 Ubiquitination
K249 Acetylation
K249 Ubiquitination
R265 Methylation
K272 Acetylation
K272 Ubiquitination
K274 Acetylation
K275 Ubiquitination
K295 Ubiquitination
K300 Ubiquitination
S304 Phosphorylation
Y322 Phosphorylation
K351 Ubiquitination
K356 Ubiquitination
K360 Acetylation
K360 Ubiquitination
T365 Phosphorylation
S384 Phosphorylation
K388 Methylation
K388 Ubiquitination
S429 Phosphorylation
K430 Acetylation
K430 Ubiquitination
T433 Phosphorylation
Y446 Phosphorylation
K458 Ubiquitination
S468 Phosphorylation
K471 Ubiquitination
K475 Ubiquitination
T486 Phosphorylation
S493 Phosphorylation
T494 Phosphorylation
T503 Phosphorylation
S554 Phosphorylation
S557 Phosphorylation
T561 Phosphorylation
S562 Phosphorylation
K588 Ubiquitination
K590 Ubiquitination
Y614 Phosphorylation
K626 Ubiquitination
K635 Ubiquitination
Y641 Phosphorylation
Y643 Phosphorylation
K648 Ubiquitination
K655 Ubiquitination
T670 Phosphorylation
T672 Phosphorylation
Y677 Phosphorylation
Y688 Phosphorylation
K691 Ubiquitination
K697 Ubiquitination
T700 Phosphorylation
K703 Ubiquitination
K714 Ubiquitination
K749 Ubiquitination
K772 Ubiquitination
K790 Ubiquitination
K804 Ubiquitination
K806 Ubiquitination
S809 Phosphorylation
K811 Acetylation
K811 Ubiquitination
T815 Phosphorylation
K823 Ubiquitination
K824 Ubiquitination
S852 Phosphorylation

研究背景

機能:

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

PTMs:

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.

サブユニット構造:

Interacts with HSPA8/HSC70 (By similarity). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD).

タンパク質ファミリー:

Belongs to the heat shock protein 70 family.

研究領域

· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum.   (View pathway)

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