製品: Phospho-ROR2 (Ser449) Antibody
カタログ: AF8451
タンパク質の説明: Rabbit polyclonal antibody to Phospho-ROR2 (Ser449)
アプリケーション: WB
反応性: Human, Mouse
予測: Pig, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 105kDa; 105kD(Calculated).
ユニプロット: Q01974
RRID: AB_2840506

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(89%), Horse(89%), Sheep(89%), Rabbit(100%), Dog(89%), Chicken(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
Phospho-ROR2 (Ser449) Antibody detects endogenous levels of ROR2 only when phosphorylated at Ser449.
RRID:
AB_2840506
引用形式: Affinity Biosciences Cat# AF8451, RRID:AB_2840506.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

BDB; BDB1; Brachydactyly type B; EC 2.7.10.1; MGC163394; Neurotrophic tyrosine kinase; Neurotrophic tyrosine kinase, receptor related 2; NTRKR2; Receptor tyrosine kinase-like orphan receptor 2; receptor-related 2; ROR2; ROR2_HUMAN; Tyrosine protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase transmembrane receptor Ror2;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Xenopus
100
Chicken
100
Rabbit
100
Pig
89
Horse
89
Sheep
89
Dog
89
Zebrafish
78
Bovine
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q01974 基板として

Site PTM Type Enzyme
K97 Ubiquitination
T157 O-Glycosylation
T438 Phosphorylation
S447 Phosphorylation
S449 Phosphorylation
K466 Ubiquitination
S469 Phosphorylation
K489 Ubiquitination
K507 Ubiquitination
K512 Ubiquitination
Y555 Phosphorylation
Y624 Phosphorylation
K626 Ubiquitination
Y645 Phosphorylation
Y646 Phosphorylation
K647 Ubiquitination
Y666 Phosphorylation
Y755 Phosphorylation
S758 Phosphorylation
S762 Phosphorylation
S782 Phosphorylation
K792 Ubiquitination
Y824 Phosphorylation
S864 Phosphorylation P49841 (GSK3B)
Y873 Phosphorylation

研究背景

機能:

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP (By similarity).

タンパク質ファミリー:

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

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