ZNF436 Antibody - #AF0427

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製品: ZNF436 Antibody
カタログ: AF0427
タンパク質の説明: Rabbit polyclonal antibody to ZNF436
アプリケーション: WB IHC IF/ICC
Cited expt.: IHC
反応性: Human, Monkey
予測: Pig, Bovine, Horse, Sheep, Dog
分子量: 50kDa; 54kD(Calculated).
ユニプロット: Q9C0F3
RRID: AB_2834317

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MS Report
HPLC Report
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WB Handbook
IHC Protocol
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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Monkey
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
ZNF436 Antibody detects endogenous levels of total ZNF436.
RRID:
AB_2834317
引用形式: Affinity Biosciences Cat# AF0427, RRID:AB_2834317.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

HGNC:20814; KIAA1710; Zfp46; Zinc finger protein 436; ZN436_HUMAN; ZNF; ZNF436;

免疫原

免疫原:

A synthesized peptide derived from human ZNF436, corresponding to a region within C-terminal amino acids.

Uniprot:

Q9C0F3(ZN436_HUMAN) >>Visit HPA database.

遺伝子(ID):
ZNF436(80818)
発現特異性:
Q9C0F3 ZN436_HUMAN:

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.

タンパク質の説明:
ZNF436 May be a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family.
タンパク質配列:
MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

May be a transcriptional repressor.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in fetal brain, heart, liver, spleen, bladder, lung, skin, skeletal muscle, stomach and pancreas.

タンパク質ファミリー:

Belongs to the krueppel C2H2-type zinc-finger protein family.

参考文献

1). Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances. EUROPEAN JOURNAL OF HISTOCHEMISTRY, 2021 (PubMed: 33478201) [IF=2.1]

Application: IHC    Species: Human    Sample: breast cancer and paracancerous tissues

Figure 1.Expression levels of ZNF436, β-catenin, EGFR and CMTM5 in breast cancer and paracancerous tissues. The expression levels of ZNF436, β-catenin and EGFR in breast cancer tissues were significantly higher than those in adjacent tissues (p<0.05); CMTM5 was highly expressed in adjacent tissues (p<0.05).

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