Phospho-PDE6G (Thr22) Antibody - #AF8299

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製品: Phospho-PDE6G (Thr22) Antibody
カタログ: AF8299
タンパク質の説明: Rabbit polyclonal antibody to Phospho-PDE6G (Thr22)
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus
分子量: 9KD; 10kD(Calculated).
ユニプロット: P18545
RRID: AB_2840361

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(88%), Xenopus(88%)
クローナリティ:
Polyclonal
特異性:
Phospho-PDE6G (Thr22) Antibody detects endogenous levels of PDE6G only when phosphorylated at Thr22.
RRID:
AB_2840361
引用形式: Affinity Biosciences Cat# AF8299, RRID:AB_2840361.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

5''-cyclic phosphodiesterase subunit gamma; CNRG_HUMAN; GMP-PDE gamma; MGC125749; PDE 6; PDE6G; PDEG; Phosphodiesterase 6G cGMP Specific; Phosphodiesterase 6G cGMP specific rog gamma; Retinal Rod Photoreceptor cGMP Phosphodiesterase gamma; Retinal rod rhodopsin sensitive cGMP 3' 5'vcyclic phosphodiesterase subunit gamma; Retinal rod rhodopsin-sensitive cGMP 3''; Rod cG PDE G; RP57;

免疫原

免疫原:
Uniprot:

P18545(CNRG_HUMAN) >>Visit HPA database.

遺伝子(ID):
PDE6G(5148)
タンパク質配列:
MNLEPPKAEFRSATRVAGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
88
Chicken
88
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P18545 基板として

Site PTM Type Enzyme
T22 Phosphorylation P27361 (MAPK3)
K25 Ubiquitination
R36 Methylation
T62 Phosphorylation A0A0S2Z3I6 (ADRBK1) , P25098 (GRK2)

研究背景

機能:

Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

サブユニット構造:

Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain.

タンパク質ファミリー:

Belongs to the rod/cone cGMP-PDE gamma subunit family.

研究領域

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Organismal Systems > Sensory system > Phototransduction.

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