Phospho-RSK3 (Thr356) Antibody - #AF8187
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| 製品: | Phospho-RSK3 (Thr356) Antibody |
| カタログ: | AF8187 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-RSK3 (Thr356) |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 83kDa; 83kD(Calculated). |
| ユニプロット: | Q15349 |
| RRID: | AB_2840249 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF8187, RRID:AB_2840249.
折りたたみ／展開
90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; Mitogen.activated protein kinase-activated protein kinase 1C; p90 RSK3; p90-RSK 2; p90RSK2; pp90RSK3; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RPS6KA2; RSK 3; RSK; RSK-3; S6K alpha; S6K alpha 2; S6K-alpha-2;
免疫原
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
- Q15349 KS6A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15349 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S26 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K94 | Acetylation | Uniprot | |
| S106 | Phosphorylation | Uniprot | |
| Y135 | Phosphorylation | Uniprot | |
| K186 | Ubiquitination | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| Y217 | Phosphorylation | Uniprot | |
| S218 | Phosphorylation | O15530 (PDPK1) , Q15349 (RPS6KA2) | Uniprot |
| T222 | Phosphorylation | Uniprot | |
| K295 | Acetylation | Uniprot | |
| T356 | Phosphorylation | Uniprot | |
| S360 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| Y426 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| Y463 | Phosphorylation | Uniprot | |
| T471 | Phosphorylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| T570 | Phosphorylation | Q15349 (RPS6KA2) | Uniprot |
| Y573 | Phosphorylation | Uniprot | |
| T574 | Phosphorylation | Uniprot | |
| T618 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| K630 | Ubiquitination | Uniprot | |
| S650 | Phosphorylation | Uniprot | |
| T662 | Phosphorylation | Uniprot | |
| S730 | Phosphorylation | Uniprot |
PTMs - Q15349 酵素として
研究背景
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity).
N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Nucleus. Cytoplasm.
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with FBXO5; cooperate to induce the metaphase arrest of early blastomeres; increases and stabilizes interaction of FBXO5 with CDC20 (By similarity).
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
研究領域
· Cellular Processes > Cell growth and death > Oocyte meiosis. (View pathway)
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Organismal Systems > Nervous system > Long-term potentiation.
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
参考文献
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